Between brackets is the number of accepted species

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- Mollusca (132 754)
- Subphylum Aculifera
- Subphylum Conchifera
- Subphylum Placophora accepted as Polyplacophora
- Superclass Aplacophora
- Class Amphineura accepted as Aculifera
- Class Bivalvia (24 992)
- Subclass Autobranchia (23 278)
- Infraclass Heteroconchia (16 634)
- Subterclass Archiheterodonta (1 205)
- Subterclass Euheterodonta (11 356)
- Subterclass Heterodonta
- Subterclass Palaeoheterodonta (4 072)
- Order Trigoniida (1 482)
- Order Unionida (2 579)
- Superfamily Deccanoidoidea N. H. Shah & Patel, 2024 †
- Superfamily Etherioidea Deshayes, 1832 (148)
- Superfamily Hyrioidea Swainson, 1840 accepted as Unionoidea Rafinesque, 1820
- Superfamily Silesunionoidea Skawina & Dzik, 2011 † (11)
- Superfamily Tamesnelloidea Van Damme & Bogan, 2015 † (2)
- Superfamily Unionoidea Rafinesque, 1820 (2 417)
- Family Cumberlandiidae Heard & Guckert, 1970 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Hyriidae Swainson, 1840 (147)
- Family Jilinoconchidae Q.-H. Ma, 1989 † accepted as Unionidae Rafinesque, 1820
- Family Liaoningiidae J.-S. Yu & G.-Y. Dong, 1993 † accepted as Sibireconchidae C. M. Kolesnikov, 1977 †
- Family Margaritanidae Ortmann, 1910 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Margaritiferidae J. Henderson, 1929 (1910) (93)
- Family Monginaiidae Delvene & Munt, 2022 † (1)
- Family Propehyridellidae Iredale, 1934 accepted as Hyriidae Swainson, 1840
- Family Sancticarolitidae Simone & Mezzalira, 1997 † (1)
- Family Tegulaedontidae Van Damme & Bogan, 2015 † (3)
- Family Unionidae Rafinesque, 1820 (2 172)
- Subfamily Alasmidontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Ambleminae Rafinesque, 1820 (428)
- Subfamily Anodontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Cuneopsinae Mongin, 1963 accepted as Oxynaiini Starobogatov, 1970
- Subfamily Gonideinae Ortmann, 1916 (185)
- Subfamily Heudeaninae Modell, 1942 accepted as Gonideinae Ortmann, 1916 (1)
- Subfamily Hyriopsinae Modell, 1942 accepted as Rectidentini Modell, 1942
- Subfamily Lamprotulinae Modell, 1942 accepted as Lamprotulini Modell, 1942
- Subfamily Lampsilinae Ihering, 1901 accepted as Lampsilini Ihering, 1901
- Subfamily Leguminaiinae Starobogatov, 1970 accepted as Gonideini Ortmann, 1916
- Subfamily Limnoscaphinae Lindholm, 1932 accepted as Rectidentini Modell, 1942
- Subfamily Margaritaninae Ortmann, 1910 accepted as Margaritiferinae J. Henderson, 1929 (1910)
- Subfamily Megalonaiadinae Heard & Guckert, 1971 accepted as Quadrulini Ihering, 1901
- Subfamily Modellnaiinae Brandt, 1974 (1)
- Subfamily Nodulariinae Starobogatov & Zatravkin, 1987 accepted as Nodulariini Starobogatov & Zatravkin, 1987
- Subfamily Parreysiinae J. Henderson, 1935 (150)
- Subfamily Physunioninae Starobogatov, 1970 accepted as Contradentini Modell, 1942
- Subfamily Pseudanodontinae Stadnichenko, 1984 accepted as Anodontini Rafinesque, 1820
- Subfamily Pseudodontinae Frierson, 1927 (60)
- Subfamily Psilunioninae Starobogatov, 1970
- Subfamily Qiyangiinae J.-H. Chen, 1983 † (66)
- Subfamily Quadrulinae Ihering, 1901 accepted as Quadrulini Ihering, 1901
- Subfamily Rectidentinae Modell, 1942 (134)
- Subfamily Strophitinae Starobogatov, 1970 accepted as Anodontini Rafinesque, 1820
- Subfamily Unionidae incertae sedis (357)
- Genus Acuneopsis X.-Z. Liu & G.-X. Zhu, 1978 † (3)
- Genus Afrohyrioides Van Damme & Bogan, 2015 † (1)
- Species Afrohyrioides jowikolensis (R. B. Newton, 1909) †
- Genus Amblemella Modell, 1969 † (3)
- Genus Antediplodon W. B. Marshall, 1929 † (18)
- Genus Anunio Lebedev, 1958 † (1)
- Genus Archaeounio Koarai & Matsukawa, 2016 † (1)
- Genus Archiparreysia Modell, 1964 †
- Genus Bisulcus Hitchcock, 1865 †
- Genus Bogatschevia Jatsko, 1972 † (8)
- Genus Coactunio Van Damme & Bogan, 2015 † (1)
- Genus Costanaia MacNeil, 1935 † (1)
- Genus Cuneopsidea Wenz, 1928 † (11)
- Genus Cuneunio Popova & Starobogatov, 1970 † (5)
- Genus Dehminaia Modell, 1969 † (1)
- Genus Diplasma Rafinesque, 1831
- Genus Ebersininaia Starobogatov, 1970 † (11)
- Genus Elrhazunio Van Damme & Bogan, 2015 † (1)
- Genus Eocuneopsis F.-X. Guo, 1988 † (9)
- Genus Eodiplodon W. B. Marshall, 1928 † accepted as Diplodon Spix, 1827
- Genus Gautieraia Van Damme & Pickford, 2010 † (1)
- Genus Germainaia Graf & Cummings, 2009 (1)
- Genus Grafunio Van Damme & Pickford, 2010 † (1)
- Genus Haasodonta McMichael, 1956 (2)
- Genus Hadrodon Yen, 1952 † (3)
- Genus Isfariopsis Martinson, 1953 † (2)
- Genus Jazkoa Starobogatov, 1970 † (6)
- Genus Jilinoconcha Q.-H. Ma, 1989 † accepted as Plesielliptio L. S. Russell, 1934 †
- Genus Jishuiconcha B.-L. Ding, J.-H. Li & Sun, 1982 † accepted as Unionelloides Z.-W. Gu, 1962 †
- Genus Kasancoviella Ragozin, 1964 † accepted as Abiella Ragozin, 1933 †
- Genus Kasankoviella [sic] † accepted as Abiella Ragozin, 1933 †
- Genus Linshuiella Q.-H. Ma, 1999 † (2)
- Genus Liopotomida Q.-H. Ma, 1999 † accepted as Unionelloides Z.-W. Gu, 1962 †
- Genus Liovetulonaia Q.-H. Ma, 1999 † accepted as Eocuneopsis F.-X. Guo, 1988 †
- Genus Malvensinaia †
- Genus Meekiella Modell, 1964 † accepted as Antediplodon W. B. Marshall, 1929 †
- Genus Megalonoidea MacNeil, 1935 † (2)
- Genus Mezounio Zakharov, 2020 † (1)
- Genus Moldavunio †
- Genus Mujanaia Delvene, Munt, Piñuela & García-Ramos, 2016 † (1)
- Genus Murraia L. S. Russell, 1932 † (3)
- Genus Napoconcha B.-Y. Huang, 1992 † (2)
- Genus Ningxiaconcha Q.-H. Ma, 1991 † accepted as Unio Philipsson, 1788
- Genus Nkondonaia Van Damme & Pickford, 2010 † (1)
- Genus Obwerukunio Van Damme & Pickford, 2010 † (1)
- Genus Pacifunio Chepalyga, 1976 † (3)
- Genus Paranodonta T. Kobayashi & K. Suzuki, 1936 † (2)
- Genus Paraptychorhynchus Starobogatov, 1970 †
- Genus Pelendunio †
- Genus Periodunio F.-X. Guo, 1988 † (1)
- Genus Plesielliptio L. S. Russell, 1934 † (18)
- Genus Pliconaias W. B. Marshall, 1929 † (1)
- Genus Prodiplodon W. B. Marshall, 1928 † accepted as Diplodon Spix, 1827
- Genus Protelliptio L. S. Russell, 1934 † (9)
- Genus Protoanodonta Delvene & R. Araujo, 2009 † (1)
- Genus Protopleurobema Delvene & R. Araujo, 2009 † (1)
- Genus Pseudelliptio G.-X. Zhu, 1976 †
- Genus Pseudobovaria W. Adam, 1957 † (3)
- Genus Pseudolanceolaria Zykin, 1980 † (1)
- Genus Pseudosturia Chepalyga, 1965 † (6)
- Genus Psilounio F.-X. Guo, 1985 † accepted as Unionelloides Z.-W. Gu, 1962 †
- Genus Psilunio Stefanescu, 1896 † (103)
- Genus Qianweiella X.-Z. Liu & Q.-H. Luo, 1981 † accepted as Unionelloides Z.-W. Gu, 1962 †
- Genus Radioplicata B.-Y. Huang, 1981 (1)
- Genus Rhabdotophorus L. S. Russell, 1935 † (4)
- Genus Rheinbraunia Schlickum & Strauch, 1979 † (1)
- Genus Ritia [sic] † accepted as Potomida Swainson, 1840
- Genus Rostrunio Van Damme & Bogan, 2015 † (1)
- Genus Rugunio Starobogatov, 1970 † (9)
- Genus Rytia Stefanescu, 1896 † accepted as Potomida Swainson, 1840
- Genus Sabbaia Cossmann, 1897 † accepted as Rytia Stefanescu, 1896 †
- Genus Saharella Mongin, 1963 † (1)
- Genus Sibinunio †
- Genus Sinzowinaia Starobogatov, 1970 † (1)
- Genus Sulcatapex Yen, 1946 † (4)
- Genus Sulcatula P. Leroy, 1940 † (4)
- Genus Sulcopotomida Starobogatov, 1970 † accepted as Potomida Swainson, 1840 (1)
- Genus Tacuaremboia S. Martinez, Figueiras & J. S. Silva, 1993 † (1)
- Genus Teisseyrinaia Starobogatov, 1970 † (2)
- Genus Teruella Mongin, 1965 † (1)
- Genus Triaslacus Bogan & P. G. Weaver, 2012 † (1)
- Genus Trisulcus Hitchcock, 1865 †
- Genus Troitskinaia Zykin, 1980 † (1)
- Genus Tuaregunio Van Damme & Bogan, 2015 † (1)
- Genus Tuberonaia Z.-W. Gu & B.-Y. Huang, 1976 † (1)
- Genus Tutuella Ragozin, 1938 † (31)
- Genus Tyraspoliconcha Jatsko, 1972 † (3)
- Genus Unioasia Martinson, Barsbold & Tolstikova, 1975 † (2)
- Genus Unionelloides Z.-W. Gu, 1962 † (21)
- Genus Valahunio †
- Genus Vanderschaliea Modell, 1943 † accepted as Alasmidonta (Vanderschaliea) Modell, 1943 †
- Genus Vetulonaia C. C. Branson, 1935 † (9)
- Genus Wenziella Modell, 1958 † accepted as Potomida Swainson, 1840
- Genus Wulongiconcha X.-Z. Liu, 1984 † accepted as Unionelloides Z.-W. Gu, 1962 †
- Genus Zaisanunio Tolstikova, 1969 † (3)
- Subfamily Unioninae Rafinesque, 1820 (790)
- Genus Strophitinae M. E. Gordon, 1981 accepted as Strophitinae Starobogatov, 1970
- Family Deccanoidea N. H. Shah & Patel, 2024 † accepted as Deccanoidoidea N. H. Shah & Patel, 2024 †
- Family Pachycardiidae L. R. Cox, 1961 † accepted as Trigonodidae Modell, 1942 †
- Family Silesunionina Skawina & Dzik, 2011 † accepted as Silesunionoidea Skawina & Dzik, 2011 †
- Genus Araripenaia V. R. Silva et al., 2020 † (1)
- Family Lyrodesmatidae P. Fischer, 1886 † (8)
- Family Pseudarcidae Scarlato & Starobogatov, 1979 † (3)
- Family Thoraliidae N. J. Morris, 1980 †
- Superorder Heteroconchia incertae sedis † (1)
- Infraclass Pteriomorphia (6 644)
- Subclass Bivalvia incertae sedis (7)
- Subclass Palaeotaxodonta accepted as Nuculida
- Subclass Paleoheterodonta accepted as Palaeoheterodonta
- Subclass Protobranchia (1 365)
- Infraclass Cryptodonta † (342)
- Class Caudofoveata (143)
- Class Cephalopoda (1 832)
- Class Conchifera accepted as Bivalvia
- Class Cricoconarida † (1)
- Class Gastropoda (102 679)
- Class Lamellibranchiata accepted as Bivalvia
- Class Loricata accepted as Polyplacophora
- Class Mollusca incertae sedis † (372)
- Class Monoplacophora (229)
- Class Pelecypoda accepted as Bivalvia
- Class Polyplacophora (1 377)
- Class Polyplaxiphora accepted as Polyplacophora
- Class Rostroconchia † (64)
- Class Scaphopoda (752)
- Class Solenoconchia accepted as Scaphopoda
- Class Solenogastres (313)
- Subclass Chaetodermomorpha accepted as Caudofoveata