1. Subfamily Aplexinae Starobogatov, 1967
   1. Genus Afrophysa Starobogatov, 1967
   2. Genus Amecanauta D. W. Taylor, 2003
   3. Genus Amuraplexa Starobogatov & Prozorova, 1989
   4. Genus Aplexa J. Fleming, 1820
   5. Genus Austrinauta D. W. Taylor, 2003
   6. Genus Caribnauta D. W. Taylor, 2003
   7. Genus Mayabina D. W. Taylor, 2003
   8. Genus Mexinauta D. W. Taylor, 2003
   9. Genus Paraplexa Starobogatov, 1989
   10. Genus Sibirenauta Starobogatov & Streletzkaja, 1967
   11. Genus Tropinauta D. W. Taylor, 2003
   12. Genus Aplecta Herrmannsen, 1846 accepted as Aplexa J. Fleming, 1820 (invalid: an incorrect subsequent spelling of Aplexa)
2. Genus Berellaia de Laubrière & Carez, 1881 †
3. Genus Hannibalina G. D. Hanna & Gester, 1963 †
4. Subfamily Physinae Fitzinger, 1833
   1. Genus Beringophysa Starobogatov & Budnikova, 1976
   2. Genus Chiapaphysa D. W. Taylor, 2003
   3. Genus Physa Draparnaud, 1801
   4. Genus Physella Haldeman, 1842
   5. Genus Stenophysa E. von Martens, 1898
   6. Genus Ultraphysella D. W. Taylor, 2003
   7. Genus Archiphysa D. W. Taylor, 2003 accepted as Physella Haldeman, 1842 (a junior synonym)
   8. Genus Costatella Dall, 1870 accepted as Physella (Costatella) Dall, 1870 represented as Physella Haldeman, 1842
   9. Genus Haitia Clench & Aguayo, 1932 accepted as Physella (Acutiana) Fagot, 1883 represented as Physella Haldeman, 1842 (synonym)
   10. Genus Laurentiphysa D. W. Taylor, 2003 accepted as Physa Draparnaud, 1801 (a junior synonym)
   11. Genus Rivicola Fitzinger, 1833 accepted as Physa Draparnaud, 1801 (Invalid: junior objective synonym of Physa, with the same type species)
   12. Genus Utahphysa D. W. Taylor, 2003 accepted as Physella Haldeman, 1842 (unaccepted > junior subjective synonym)
5. Genus Prophysa Bandel, 1991 †
6. Genus Petrophysa Pilsbry, 1926 accepted as Physella Haldeman, 1842

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