Between brackets is the number of accepted species

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- Mollusca (132 754)
- Subphylum Aculifera
- Subphylum Conchifera
- Subphylum Placophora accepted as Polyplacophora
- Superclass Aplacophora
- Class Amphineura accepted as Aculifera
- Class Bivalvia (24 992)
- Subclass Autobranchia (23 278)
- Infraclass Heteroconchia (16 634)
- Subterclass Archiheterodonta (1 205)
- Subterclass Euheterodonta (11 356)
- Subterclass Heterodonta
- Subterclass Palaeoheterodonta (4 072)
- Order Trigoniida (1 482)
- Order Unionida (2 579)
- Superfamily Deccanoidoidea N. H. Shah & Patel, 2024 †
- Superfamily Etherioidea Deshayes, 1832 (148)
- Superfamily Hyrioidea Swainson, 1840 accepted as Unionoidea Rafinesque, 1820
- Superfamily Silesunionoidea Skawina & Dzik, 2011 † (11)
- Superfamily Tamesnelloidea Van Damme & Bogan, 2015 † (2)
- Superfamily Unionoidea Rafinesque, 1820 (2 417)
- Family Cumberlandiidae Heard & Guckert, 1970 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Hyriidae Swainson, 1840 (147)
- Family Jilinoconchidae Q.-H. Ma, 1989 † accepted as Unionidae Rafinesque, 1820
- Family Liaoningiidae J.-S. Yu & G.-Y. Dong, 1993 † accepted as Sibireconchidae C. M. Kolesnikov, 1977 †
- Family Margaritanidae Ortmann, 1910 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Margaritiferidae J. Henderson, 1929 (1910) (93)
- Family Monginaiidae Delvene & Munt, 2022 † (1)
- Family Propehyridellidae Iredale, 1934 accepted as Hyriidae Swainson, 1840
- Family Sancticarolitidae Simone & Mezzalira, 1997 † (1)
- Family Tegulaedontidae Van Damme & Bogan, 2015 † (3)
- Family Unionidae Rafinesque, 1820 (2 172)
- Subfamily Alasmidontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Ambleminae Rafinesque, 1820 (428)
- Tribe Amblemini Rafinesque, 1820 (13)
- Tribe Lampsilini Ihering, 1901 (191)
- Genus Actinonaias Crosse & P. Fischer, 1894 (9)
- Genus Aeglia Swainson, 1840 accepted as Lampsilis Rafinesque, 1820
- Genus Amygdalonaias Crosse & P. Fischer, 1894 accepted as Truncilla Rafinesque, 1819
- Genus Amygdalonajas Crosse & P. Fischer, 1894 accepted as Amygdalonaias Crosse & P. Fischer, 1894
- Genus Arotonaias E. von Martens, 1900 (3)
- Genus Atlanticoncha C. H. Smith, J. M. Pfeiffer & N. A. Johnson, 2020 (1)
- Genus Cambarunio Watters, 2018 (7)
- Genus Capsaeformis Frierson, 1927 accepted as Epioblasma Rafinesque, 1831
- Genus Carunculina C. T. Simpson, 1898 accepted as Toxolasma Rafinesque, 1831
- Genus Conchodromus F. Haas, 1930 accepted as Dromus C. T. Simpson, 1900
- Genus Conradilla Ortmann, 1921 accepted as Lemiox Rafinesque, 1831
- Genus Corunculina C. T. Simpson, 1898 accepted as Carunculina C. T. Simpson, 1898
- Genus Crenodonta Schlüter, 1838 accepted as Ellipsaria Rafinesque, 1820
- Genus Cyprogenia Agassiz, 1852 (2)
- Genus Cyrtonaias Crosse & P. Fischer, 1894 (6)
- Genus Delphinonaias Crosse & P. Fischer, 1894 (2)
- Genus Disconaias Crosse & P. Fischer, 1894 (6)
- Genus Dromas Lindahl, 1906 accepted as Dromus C. T. Simpson, 1900
- Genus Dromus C. T. Simpson, 1900 (1)
- Genus Dysnomia Agassiz, 1852 accepted as Epioblasma Rafinesque, 1831
- Genus Ellipsaria Rafinesque, 1820 (1)
- Genus Epioblasma Rafinesque, 1831 (30)
- Genus Friersonia Ortmann, 1912 (1)
- Genus Glebula Conrad, 1853 (2)
- Genus Hamiota Roe & Hartfield, 2005 (4)
- Genus Lampsida [sic] accepted as Lampsilis Rafinesque, 1820
- Genus Lampsilis Rafinesque, 1820 (36)
- Genus Lasmonos Rafinesque, 1831 accepted as Potamilus Rafinesque, 1818
- Genus Lastena Rafinesque, 1820 accepted as Potamilus Rafinesque, 1818
- Genus Leaunio Watters, 2018 (5)
- Genus Lemiox Rafinesque, 1831 (1)
- Genus Lenelliptio C. M. Kolesnikov, 1980 † (3)
- Genus Leptodea Rafinesque, 1820 accepted as Potamilus Rafinesque, 1818
- Genus Ligumia Swainson, 1840 (7)
- Subgenus Ligumia (Micromya) Agassiz, 1852 accepted as Paetulunio Watters, 2018
- Species Ligumia australis (C. T. Simpson, 1900) accepted as Hamiota australis (C. T. Simpson, 1900)
- Species Ligumia barbouri (C. A. White, 1895) †
- Species Ligumia borealis (Gray, 1882) accepted as Lampsilis radiata (Gmelin, 1791)
- Species Ligumia bowlingi (MacNeil, 1935) †
- Species Ligumia bracteata (Gould, 1855) accepted as Lampsilis bracteata (A. Gould, 1855)
- Species Ligumia carinata accepted as Solenaia carinata (Heude, 1877)
- Species Ligumia consueta (Whiteaves, 1885) † accepted as Lampsilis consuetus (Whiteaves, 1885) †
- Species Ligumia couesi (C. A. White, 1877) †
- Species Ligumia delumbis (Conrad, 1834) accepted as Villosa delumbis (Conrad, 1834)
- Species Ligumia fabacea (I. Lea, 1861) accepted as Villosa umbrans (I. Lea, 1857)
- Species Ligumia farri (Stanton, 1903) † accepted as Lampsilis farri (Stanton, 1903) †
- Species Ligumia gracilior (I. Lea, 1856) accepted as Villosa vibex (Conrad, 1834)
- Species Ligumia iris (I. Lea, 1829) accepted as Villosa iris (I. Lea, 1829)
- Species Ligumia latissima (Rafinesque, 1820) accepted as Ligumia recta (Lamarck, 1819)
- Species Ligumia lienosa (Conrad, 1834) accepted as Villosa lienosa (Conrad, 1834)
- Species Ligumia menkiana (I. Lea, 1838) accepted as Cambarunio taeniatus pictus (I. Lea, 1834)
- Species Ligumia modioliformis (I. Lea, 1834) accepted as Villosa vibex (Conrad, 1834)
- Species Ligumia nasuta (Say, 1817) accepted as Sagittunio nasutus (Say, 1817)
- Species Ligumia nebulosa (Conrad, 1834) accepted as Villosa nebulosa (Conrad, 1834)
- Species Ligumia nervosa (Rafinesque, 1820) accepted as Megalonaias nervosa (Rafinesque, 1820)
- Species Ligumia ochracea (Say, 1817) accepted as Leptodea ochracea (Say, 1817)
- Species Ligumia ogeecheensis (Conrad, 1849) accepted as Villosa delumbis (Conrad, 1834)
- Species Ligumia perpasta (I. Lea, 1861) accepted as Lampsilis straminea (Conrad, 1834)
- Species Ligumia picta (I. Lea, 1834) accepted as Cambarunio taeniatus pictus (I. Lea, 1834)
- Species Ligumia powellii (I. Lea, 1852) accepted as Lampsilis powellii (I. Lea, 1852)
- Species Ligumia prattii (I. Lea, 1858) accepted as Villosa lienosa (Conrad, 1834)
- Species Ligumia propria (I. Lea, 1865) accepted as Villosa umbrans (I. Lea, 1857)
- Species Ligumia radians (I. Lea, 1857) accepted as Villosa nebulosa (Conrad, 1834)
- Species Ligumia radiata (Gmelin, 1791) accepted as Lampsilis radiata (Gmelin, 1791)
- Species Ligumia recta (Lamarck, 1819)
- Species Ligumia reeviana (I. Lea, 1852) accepted as Lampsilis reeveiana (I. Lea, 1852)
- Species Ligumia siliquoidea (Barnes, 1823) accepted as Lampsilis siliquoidea (Barnes, 1823)
- Species Ligumia spinnhirni Modell, 1950 †
- Species Ligumia stagnalis (Conrad, 1849) accepted as Villosa vibex (Conrad, 1834)
- Species Ligumia stantoni (C. A. White, 1907) † accepted as Plesielliptio stantoni (C. A. White, 1907) †
- Species Ligumia streckeri (Frierson, 1927) accepted as Lampsilis streckeri Frierson, 1927
- Species Ligumia subangulata (I. Lea, 1840) accepted as Hamiota subangulata (I. Lea, 1840)
- Species Ligumia subrostrata (Say, 1831) accepted as Sagittunio subrostratus (Say, 1831)
- Species Ligumia taeniata (Conrad, 1834) accepted as Villosa taeniata (Conrad, 1834)
- Species Ligumia tellinoides (J. Hall, 1845) †
- Species Ligumia tenera (I. Lea, 1840) accepted as Villosa iris (I. Lea, 1829)
- Species Ligumia teres (Rafinesque, 1820) accepted as Lampsilis teres (Rafinesque, 1820)
- Species Ligumia vanuxemensis (I. Lea, 1838) accepted as Villosa vanuxemensis (I. Lea, 1838)
- Species Ligumia vetusta (Meek, 1860) † accepted as Plesielliptio vetustus (Meek, 1860) †
- Species Ligumia vibex (Conrad, 1834) accepted as Villosa vibex (Conrad, 1834)
- Species Ligumia virescens (I. Lea, 1858) accepted as Lampsilis virescens (I. Lea, 1858)
- Species Ligumia whitei (J. Henderson, 1918) †
- Species Ligumia zeigleriana (I. Lea, 1838) accepted as Leaunio vanuxemensis (I. Lea, 1838)
- Genus Limnadea Agassiz, 1846 accepted as Potamilus Rafinesque, 1818
- Genus Luteacarnea Frierson, 1927 accepted as Obovaria Rafinesque, 1819
- Genus Medionidus C. T. Simpson, 1900 (7)
- Genus Mesonaias Crosse & P. Fischer, 1894 accepted as Cyrtonaias Crosse & P. Fischer, 1894
- Genus Metaptera Rafinesque, 1820 accepted as Potamilus Rafinesque, 1818
- Genus Micromya Agassiz, 1852 accepted as Paetulunio Watters, 2018
- Genus Monelagmus Agassiz, 1846 accepted as Leptodea Rafinesque, 1820
- Genus Monelasmus Agassiz, 1846 accepted as Potamilus Rafinesque, 1818
- Genus Naidea Swainson, 1840 accepted as Potamilus Rafinesque, 1818
- Genus Nedionidus [sic] accepted as Medionidus C. T. Simpson, 1900
- Genus Oblicaria Rafinesque, 1820 accepted as Obliquaria Rafinesque, 1820
- Genus Obliquaria Rafinesque, 1820 (1)
- Genus Obliquata Frierson, 1927 accepted as Epioblasma Rafinesque, 1831
- Genus Obovaria Rafinesque, 1819 (7)
- Genus Ortmanniana Frierson, 1927 (2)
- Genus Pachynaias Crosse & P. Fischer, 1894 (2)
- Genus Paetulunio Watters, 2018 (1)
- Genus Paraptera Ortmann, 1911 accepted as Potamilus Rafinesque, 1818
- Genus Pareptera Ortmann, 1911 accepted as Leptodea Rafinesque, 1820
- Genus Penita Frierson, 1927 accepted as Epioblasma Rafinesque, 1831
- Genus Pilea C. T. Simpson, 1900 accepted as Epioblasma Rafinesque, 1831
- Genus Plagiola Rafinesque, 1819 accepted as Ptychobranchus C. T. Simpson, 1900
- Genus Plagiolopsis Thiele, 1934 accepted as Ellipsaria Rafinesque, 1820
- Genus Potamilus Rafinesque, 1818 (12)
- Genus Proptera Rafinesque, 1819 accepted as Potamilus Rafinesque, 1818
- Genus Pseudoon C. T. Simpson, 1900 accepted as Obovaria Rafinesque, 1819
- Genus Ptychobranchus C. T. Simpson, 1900 (7)
- Genus Rotundaria Rafinesque, 1820 accepted as Obovaria Rafinesque, 1819
- Genus Sagittunio Watters, 2018 (4)
- Genus Scalenilla Ortmann & B. Walker, 1922 accepted as Epioblasma Rafinesque, 1831
- Genus Simpsonunio Starobogatov, 1970 accepted as Lampsilis Rafinesque, 1820
- Genus Stenelasma Herrmannsen, 1849 accepted as Potamilus Rafinesque, 1818
- Genus Striata Frierson, 1927 accepted as Obovaria Rafinesque, 1819
- Genus Subtentus Frierson, 1927 accepted as Ptychobranchus C. T. Simpson, 1900
- Genus Symphynota I. Lea, 1829 accepted as Potamilus Rafinesque, 1818
- Genus Torulosa Frierson, 1927 accepted as Epioblasma Rafinesque, 1831
- Genus Toxelasma Agassiz, 1846 accepted as Toxolasma Rafinesque, 1831
- Genus Toxolasma Rafinesque, 1831 (7)
- Genus Troncilla Rafinesque, 1819 accepted as Truncilla Rafinesque, 1819
- Genus Truncilla Rafinesque, 1819 (4)
- Genus Truncillopsis Ortmann & B. Walker, 1922 accepted as Epioblasma Rafinesque, 1831
- Genus Venustaconcha Frierson, 1927 (6)
- Genus Villosa Frierson, 1927 (4)
- Tribe Pleurobemini Hannibal, 1912 (104)
- Tribe Popenaiadini Heard & Guckert, 1971 (69)
- Tribe Quadrulini Ihering, 1901 (51)
- Genus Symphinota [sic] accepted as Symphynota I. Lea, 1829
- Genus Symphonota [sic] accepted as Symphynota I. Lea, 1829
- Subfamily Anodontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Cuneopsinae Mongin, 1963 accepted as Oxynaiini Starobogatov, 1970
- Subfamily Gonideinae Ortmann, 1916 (185)
- Subfamily Heudeaninae Modell, 1942 accepted as Gonideinae Ortmann, 1916 (1)
- Subfamily Hyriopsinae Modell, 1942 accepted as Rectidentini Modell, 1942
- Subfamily Lamprotulinae Modell, 1942 accepted as Lamprotulini Modell, 1942
- Subfamily Lampsilinae Ihering, 1901 accepted as Lampsilini Ihering, 1901
- Subfamily Leguminaiinae Starobogatov, 1970 accepted as Gonideini Ortmann, 1916
- Subfamily Limnoscaphinae Lindholm, 1932 accepted as Rectidentini Modell, 1942
- Subfamily Margaritaninae Ortmann, 1910 accepted as Margaritiferinae J. Henderson, 1929 (1910)
- Subfamily Megalonaiadinae Heard & Guckert, 1971 accepted as Quadrulini Ihering, 1901
- Subfamily Modellnaiinae Brandt, 1974 (1)
- Subfamily Nodulariinae Starobogatov & Zatravkin, 1987 accepted as Nodulariini Starobogatov & Zatravkin, 1987
- Subfamily Parreysiinae J. Henderson, 1935 (150)
- Subfamily Physunioninae Starobogatov, 1970 accepted as Contradentini Modell, 1942
- Subfamily Pseudanodontinae Stadnichenko, 1984 accepted as Anodontini Rafinesque, 1820
- Subfamily Pseudodontinae Frierson, 1927 (60)
- Subfamily Psilunioninae Starobogatov, 1970
- Subfamily Qiyangiinae J.-H. Chen, 1983 † (66)
- Subfamily Quadrulinae Ihering, 1901 accepted as Quadrulini Ihering, 1901
- Subfamily Rectidentinae Modell, 1942 (134)
- Subfamily Strophitinae Starobogatov, 1970 accepted as Anodontini Rafinesque, 1820
- Subfamily Unionidae incertae sedis (357)
- Subfamily Unioninae Rafinesque, 1820 (790)
- Genus Strophitinae M. E. Gordon, 1981 accepted as Strophitinae Starobogatov, 1970
- Family Deccanoidea N. H. Shah & Patel, 2024 † accepted as Deccanoidoidea N. H. Shah & Patel, 2024 †
- Family Pachycardiidae L. R. Cox, 1961 † accepted as Trigonodidae Modell, 1942 †
- Family Silesunionina Skawina & Dzik, 2011 † accepted as Silesunionoidea Skawina & Dzik, 2011 †
- Genus Araripenaia V. R. Silva et al., 2020 † (1)
- Family Lyrodesmatidae P. Fischer, 1886 † (8)
- Family Pseudarcidae Scarlato & Starobogatov, 1979 † (3)
- Family Thoraliidae N. J. Morris, 1980 †
- Superorder Heteroconchia incertae sedis † (1)
- Infraclass Pteriomorphia (6 644)
- Subclass Bivalvia incertae sedis (7)
- Subclass Palaeotaxodonta accepted as Nuculida
- Subclass Paleoheterodonta accepted as Palaeoheterodonta
- Subclass Protobranchia (1 365)
- Infraclass Cryptodonta † (342)
- Class Caudofoveata (143)
- Class Cephalopoda (1 832)
- Class Conchifera accepted as Bivalvia
- Class Cricoconarida † (1)
- Class Gastropoda (102 679)
- Class Lamellibranchiata accepted as Bivalvia
- Class Loricata accepted as Polyplacophora
- Class Mollusca incertae sedis † (372)
- Class Monoplacophora (229)
- Class Pelecypoda accepted as Bivalvia
- Class Polyplacophora (1 377)
- Class Polyplaxiphora accepted as Polyplacophora
- Class Rostroconchia † (64)
- Class Scaphopoda (752)
- Class Solenoconchia accepted as Scaphopoda
- Class Solenogastres (313)
- Subclass Chaetodermomorpha accepted as Caudofoveata