Between brackets is the number of accepted species

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- Mollusca (132 791)
- Subphylum Aculifera
- Subphylum Conchifera
- Subphylum Placophora accepted as Polyplacophora
- Superclass Aplacophora
- Class Amphineura accepted as Aculifera
- Class Bivalvia (25 009)
- Subclass Autobranchia (23 295)
- Infraclass Heteroconchia (16 637)
- Subterclass Archiheterodonta (1 208)
- Subterclass Euheterodonta (11 356)
- Subterclass Heterodonta
- Subterclass Palaeoheterodonta (4 072)
- Order Trigoniida (1 482)
- Order Unionida (2 579)
- Superfamily Deccanoidoidea N. H. Shah & Patel, 2024 †
- Superfamily Etherioidea Deshayes, 1832 (148)
- Superfamily Hyrioidea Swainson, 1840 accepted as Unionoidea Rafinesque, 1820
- Superfamily Silesunionoidea Skawina & Dzik, 2011 † (11)
- Superfamily Tamesnelloidea Van Damme & Bogan, 2015 † (2)
- Superfamily Unionoidea Rafinesque, 1820 (2 417)
- Family Cumberlandiidae Heard & Guckert, 1970 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Hyriidae Swainson, 1840 (147)
- Subfamily Castaliinae Lange de Morretes, 1949 accepted as Castaliini Lange de Morretes, 1949
- Subfamily Hyriinae Swainson, 1840 (121)
- Tribe Castaliini Lange de Morretes, 1949 (20)
- Tribe Hyridellini McMichael, 1956 (25)
- Genus Cucumerunio Iredale, 1934 (1)
- Species Cucumerunio novaehollandiae (Gray, 1834)
- Species Cucumerunio websteri (C. T. Simpson, 1902) accepted as Echyridella aucklandica (J. E. Gray, 1843)
- Genus Echyridella McMichael & Hiscock, 1958 (4)
- Genus Hyridella Swainson, 1840 (11)
- Genus Megalovirgus Hocknull, 2000 † (5)
- Genus Mesohyridella McMichael, 1957 † (1)
- Genus Palaeohyridella Hocknull, 2000 † (1)
- Genus Protohyridella Cotton & Gabriel, 1932 accepted as Hyridella (Protohyridella) Cotton & Gabriel, 1932
- Genus Virgus C. T. Simpson, 1900 (2)
- Tribe Hyriini Swainson, 1840 (5)
- Tribe Rhipidodontini Starobogatov, 1970 (71)
- Genus Cyclomya C. T. Simpson, 1900 accepted as Rhipidodonta Mörch, 1853
- Subfamily Velesunioninae Iredale, 1934 (24)
- Genus Aparcthyria Iredale, 1934 accepted as Velesunio Iredale, 1934
- Genus Centralhyria Iredale, 1934 accepted as Velesunio Iredale, 1934
- Genus Cucumaria Conrad, 1853 accepted as Cucumerunio Iredale, 1934
- Genus Florenceia Mezzalira, 1974 † (1)
- Genus Hyria Lamarck, 1819 accepted as Prisodon Schumacher, 1817 (1)
- Genus Hyridunio Iredale, 1934 accepted as Hyridella Swainson, 1840
- Genus Leiovirgus F. Haas, 1912 accepted as Hyridella Swainson, 1840
- Genus Lortiella Iredale, 1934 accepted as Lortiella Modell, 1942
- Genus Propehyridella Cotton & Gabriel, 1932 accepted as Hyridella Swainson, 1840
- Genus Quaesithyria Iredale, 1943 accepted as Alathyria Iredale, 1934
- Genus Rugoshyria Iredale, 1934 accepted as Hyridella Swainson, 1840
- Genus Unis F. W. Hutton, 1883 accepted as Unio Philipsson, 1788
- Family Jilinoconchidae Q.-H. Ma, 1989 † accepted as Unionidae Rafinesque, 1820
- Family Liaoningiidae J.-S. Yu & G.-Y. Dong, 1993 † accepted as Sibireconchidae C. M. Kolesnikov, 1977 †
- Family Margaritanidae Ortmann, 1910 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Margaritiferidae J. Henderson, 1929 (1910) (93)
- Family Monginaiidae Delvene & Munt, 2022 † (1)
- Family Propehyridellidae Iredale, 1934 accepted as Hyriidae Swainson, 1840
- Family Sancticarolitidae Simone & Mezzalira, 1997 † (1)
- Family Tegulaedontidae Van Damme & Bogan, 2015 † (3)
- Family Unionidae Rafinesque, 1820 (2 172)
- Family Deccanoidea N. H. Shah & Patel, 2024 † accepted as Deccanoidoidea N. H. Shah & Patel, 2024 †
- Family Pachycardiidae L. R. Cox, 1961 † accepted as Trigonodidae Modell, 1942 †
- Family Silesunionina Skawina & Dzik, 2011 † accepted as Silesunionoidea Skawina & Dzik, 2011 †
- Genus Araripenaia V. R. Silva et al., 2020 † (1)
- Family Lyrodesmatidae P. Fischer, 1886 † (8)
- Family Pseudarcidae Scarlato & Starobogatov, 1979 † (3)
- Family Thoraliidae N. J. Morris, 1980 †
- Superorder Heteroconchia incertae sedis † (1)
- Infraclass Pteriomorphia (6 658)
- Subclass Bivalvia incertae sedis (7)
- Subclass Palaeotaxodonta accepted as Nuculida
- Subclass Paleoheterodonta accepted as Palaeoheterodonta
- Subclass Protobranchia (1 365)
- Infraclass Cryptodonta † (342)
- Class Caudofoveata (143)
- Class Cephalopoda (1 834)
- Class Conchifera accepted as Bivalvia
- Class Cricoconarida † (1)
- Class Gastropoda (102 697)
- Class Lamellibranchiata accepted as Bivalvia
- Class Loricata accepted as Polyplacophora
- Class Mollusca incertae sedis † (372)
- Class Monoplacophora (229)
- Class Pelecypoda accepted as Bivalvia
- Class Polyplacophora (1 377)
- Class Polyplaxiphora accepted as Polyplacophora
- Class Rostroconchia † (64)
- Class Scaphopoda (752)
- Class Solenoconchia accepted as Scaphopoda
- Class Solenogastres (313)
- Subclass Chaetodermomorpha accepted as Caudofoveata