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- Mollusca (132 754)
- Subphylum Aculifera
- Subphylum Conchifera
- Subphylum Placophora accepted as Polyplacophora
- Superclass Aplacophora
- Class Amphineura accepted as Aculifera
- Class Bivalvia (24 992)
- Subclass Autobranchia (23 278)
- Infraclass Heteroconchia (16 634)
- Subterclass Archiheterodonta (1 205)
- Subterclass Euheterodonta (11 356)
- Subterclass Heterodonta
- Subterclass Palaeoheterodonta (4 072)
- Order Trigoniida (1 482)
- Order Unionida (2 579)
- Superfamily Deccanoidoidea N. H. Shah & Patel, 2024 †
- Superfamily Etherioidea Deshayes, 1832 (148)
- Superfamily Hyrioidea Swainson, 1840 accepted as Unionoidea Rafinesque, 1820
- Superfamily Silesunionoidea Skawina & Dzik, 2011 † (11)
- Superfamily Tamesnelloidea Van Damme & Bogan, 2015 † (2)
- Superfamily Unionoidea Rafinesque, 1820 (2 417)
- Family Cumberlandiidae Heard & Guckert, 1970 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Hyriidae Swainson, 1840 (147)
- Family Jilinoconchidae Q.-H. Ma, 1989 † accepted as Unionidae Rafinesque, 1820
- Family Liaoningiidae J.-S. Yu & G.-Y. Dong, 1993 † accepted as Sibireconchidae C. M. Kolesnikov, 1977 †
- Family Margaritanidae Ortmann, 1910 accepted as Margaritiferidae J. Henderson, 1929 (1910)
- Family Margaritiferidae J. Henderson, 1929 (1910) (93)
- Family Monginaiidae Delvene & Munt, 2022 † (1)
- Family Propehyridellidae Iredale, 1934 accepted as Hyriidae Swainson, 1840
- Family Sancticarolitidae Simone & Mezzalira, 1997 † (1)
- Family Tegulaedontidae Van Damme & Bogan, 2015 † (3)
- Family Unionidae Rafinesque, 1820 (2 172)
- Subfamily Alasmidontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Ambleminae Rafinesque, 1820 (428)
- Tribe Amblemini Rafinesque, 1820 (13)
- Tribe Lampsilini Ihering, 1901 (191)
- Tribe Pleurobemini Hannibal, 1912 (104)
- Tribe Popenaiadini Heard & Guckert, 1971 (69)
- Tribe Quadrulini Ihering, 1901 (51)
- Genus Amphinaias Crosse & P. Fischer, 1894 accepted as Quadrula Rafinesque, 1820
- Genus Bullata Frierson, 1927 accepted as Cyclonaias Pilsbry, 1922
- Genus Cyclonaias Pilsbry, 1922 (1)
- Genus Eonaias W. B. Marshall, 1929 † (1)
- Genus Magalonaias Utterback, 1915 accepted as Megalonaias Utterback, 1915
- Genus Megalonaias Utterback, 1915 (2)
- Genus Orthonymus Agassiz, 1852 accepted as Theliderma Swainson, 1840
- Genus Proparreysia Pilsbry, 1921 † (14)
- Genus Protamblema Modell, 1957 † (2)
- Genus Pustulosa Frierson, 1927 (9)
- Genus Quadrula Rafinesque, 1820 (9)
- Subgenus Quadrula (Amphinaias) Crosse & P. Fischer, 1894 accepted as Quadrula Rafinesque, 1820
- Subgenus Quadrula (Bullata) Frierson, 1927 accepted as Pustulosa Frierson, 1927
- Subgenus Quadrula (Crenodonta) Schlüter, 1838 accepted as Quadrula Rafinesque, 1820
- Subgenus Quadrula (Cyclonaias) Pilsbry, 1922 accepted as Cyclonaias Pilsbry, 1922
- Subgenus Quadrula (Discomya) C. T. Simpson, 1900 accepted as Discomya C. T. Simpson, 1900
- Subgenus Quadrula (Fusconaia) C. T. Simpson, 1900 accepted as Fusconaia C. T. Simpson, 1900
- Subgenus Quadrula (Lamprotula) C. T. Simpson, 1900 accepted as Lamprotula C. T. Simpson, 1900
- Subgenus Quadrula (Luteacarnea) Frierson, 1927 accepted as Plethobasus C. T. Simpson, 1900
- Subgenus Quadrula (Obliquaria) Rafinesque, 1820 accepted as Obliquaria Rafinesque, 1820
- Subgenus Quadrula (Obliquata) Frierson, 1927 accepted as Epioblasma Rafinesque, 1831
- Species Quadrula (Obliquata) catilla (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula (Obliquata) catillus (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula (Obliquata) coccinea (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Subspecies Quadrula (Obliquata) coccinea cunea (Conrad, 1838) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Subspecies Quadrula (Obliquata) coccinea magnalacustris (C. T. Simpson, 1914) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Subspecies Quadrula (Obliquata) coccinea solida (I. Lea, 1839) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula (Obliquata) cordata (Rafinesque, 1820) accepted as Pleurobema cordatum (Rafinesque, 1820)
- Species Quadrula (Obliquata) friersoni (B. H. Wright, 1896) accepted as Pleurobema riddellii (I. Lea, 1862)
- Species Quadrula (Obliquata) missouriensis (W. A. Marsh, 1901) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula (Obliquata) obliquata (Rafinesque, 1820) accepted as Epioblasma obliquata (Rafinesque, 1820)
- Species Quadrula (Obliquata) ridellii (I. Lea, 1862) accepted as Pleurobema riddellii (I. Lea, 1862)
- Subgenus Quadrula (Orthonymus) Agassiz, 1852 accepted as Theliderma Swainson, 1840
- Subgenus Quadrula (Pleuronaia) Frierson, 1927 accepted as Pleuronaia Frierson, 1927
- Subgenus Quadrula (Pustulosa) Frierson, 1927 accepted as Pustulosa Frierson, 1927
- Subgenus Quadrula (Quadrula) Rafinesque, 1820 accepted as Quadrula Rafinesque, 1820
- Subgenus Quadrula (Quincuncina) Ortmann, 1922 accepted as Fusconaia C. T. Simpson, 1900
- Subgenus Quadrula (Rotundaria) Rafinesque, 1820 accepted as Obovaria Rafinesque, 1819
- Subgenus Quadrula (Striata) Frierson, 1927 accepted as Obovaria Rafinesque, 1819
- Subgenus Quadrula (Theliderma) Swainson, 1840 accepted as Theliderma Swainson, 1840
- Subgenus Quadrula (Tritogonia) Agassiz, 1852 accepted as Tritogonia Agassiz, 1852
- Species Quadrula andrewsii W. A. Marsh, 1902 accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula apiculata (Say, 1829) accepted as Quadrula quadrula (Rafinesque, 1820)
- Species Quadrula archeri Frierson, 1905 accepted as Pustulosa archeri (Frierson, 1905)
- Species Quadrula argentea (I. Lea, 1841) accepted as Pleurobema oviforme (Conrad, 1834)
- Species Quadrula askewi (W. A. Marsh, 1896) accepted as Fusconaia askewi (W. A. Marsh, 1896)
- Species Quadrula aspera (I. Lea, 1831) accepted as Quadrula apiculata (Say, 1829)
- Species Quadrula asperata (I. Lea, 1861) accepted as Cyclonaias asperata (I. Lea, 1861)
- Species Quadrula aurea (I. Lea, 1859) accepted as Rotundaria aurea (I. Lea, 1859)
- Species Quadrula babori Petrbok, 1912 † accepted as Unio babori (Petrbok, 1912) †
- Species Quadrula barnesiana (I. Lea, 1838) accepted as Pleuronaia barnesiana (I. Lea, 1838)
- Species Quadrula beauchampii W. A. Marsh, 1902 accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula biangulata J. P. E. Morrison, 1942 accepted as Theliderma intermedia (Conrad, 1836)
- Species Quadrula boykiniana (I. Lea, 1840) accepted as Megalonaias nervosa (Rafinesque, 1820)
- Species Quadrula bullata (Rafinesque, 1820) accepted as Rotundaria pustulosa (I. Lea, 1831)
- Species Quadrula cahabensis (I. Lea, 1871) accepted as Rotundaria asperata (I. Lea, 1861)
- Species Quadrula catilla (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula catillus (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula cerina (Conrad, 1838) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula chunii (I. Lea, 1862) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula coccinea (Conrad, 1836) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula conjugans (B. H. Wright, 1899) accepted as Tritogonia verrucosa (Rafinesque, 1820)
- Species Quadrula cooperiana (I. Lea, 1834) accepted as Plethobasus cooperianus (I. Lea, 1834)
- Species Quadrula cor (Conrad, 1834) accepted as Fusconaia cor (Conrad, 1834)
- Species Quadrula cordata (Rafinesque, 1820) accepted as Pleurobema cordatum (Rafinesque, 1820)
- Species Quadrula cordatum (Rafinesque, 1820) accepted as Pleurobema cordatum (Rafinesque, 1820)
- Species Quadrula couchiana (I. Lea, 1860)
- Species Quadrula cuneolus (I. Lea, 1840) accepted as Fusconaia cuneolus (I. Lea, 1840)
- Species Quadrula cylindrica (Say, 1817) accepted as Theliderma cylindrica (Say, 1817)
- Species Quadrula cylindricoides (Whitfield, 1907) †
- Species Quadrula dolabelloides (I. Lea, 1840) accepted as Pleuronaia dolabelloides (I. Lea, 1840)
- Species Quadrula ebenum (I. Lea, 1831) accepted as Reginaia ebenus (I. Lea, 1831)
- Species Quadrula ebenus (I. Lea, 1831) accepted as Reginaia ebenus (I. Lea, 1831)
- Species Quadrula elliottii (I. Lea, 1857) accepted as Amblema elliottii (I. Lea, 1857)
- Species Quadrula flava (Rafinesque, 1820) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula flexuosa C. T. Simpson, 1900 accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula forsheyi (I. Lea, 1859) accepted as Quadrula apiculata (Say, 1829)
- Species Quadrula fragosa (Conrad, 1835)
- Species Quadrula friersoni (B. H. Wright, 1896) accepted as Pleurobema riddellii (I. Lea, 1862)
- Species Quadrula georgiana (I. Lea, 1841) accepted as Pleurobema georgianum (I. Lea, 1841)
- Species Quadrula granifera (I. Lea, 1838) accepted as Rotundaria tuberculata (Rafinesque, 1820)
- Species Quadrula guatemalensis C. T. Simpson, 1900 accepted as Psoronaias guatemalensis (C. T. Simpson, 1900)
- Species Quadrula haroldi (Reeside, 1927) † accepted as Diplodon haroldi Reeside, 1927 †
- Species Quadrula heros (Say, 1829) accepted as Megalonaias nervosa (Rafinesque, 1820)
- Species Quadrula holmesiana (C. A. White, 1877) † accepted as Proparreysia holmesiana (C. A. White, 1877) †
- Species Quadrula houstonensis (I. Lea, 1859) accepted as Rotundaria houstonensis (I. Lea, 1859)
- Species Quadrula infucata (Conrad, 1834) accepted as Rotundaria infucata (Conrad, 1834)
- Species Quadrula intermedia (Conrad, 1836) accepted as Theliderma intermedia (Conrad, 1836)
- Species Quadrula keineriana (I. Lea, 1852) accepted as Rotundaria kieneriana (I. Lea, 1852)
- Species Quadrula kieneriana (I. Lea, 1853) accepted as Rotundaria kieneriana (I. Lea, 1852)
- Species Quadrula kirtlandiana (I. Lea, 1834) accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula kleiniana (I. Lea, 1852) accepted as Rotundaria kleiniana (I. Lea, 1852)
- Species Quadrula lacrymosa (I. Lea, 1827) accepted as Quadrula quadrula (Rafinesque, 1820)
- Species Quadrula lananensis Frierson, 1901 accepted as Fusconaia askewi (W. A. Marsh, 1896)
- Species Quadrula mclearni (Dyer, 1930) † accepted as Proparreysia mclearni (Dyer, 1930) †
- Species Quadrula meredithi (I. Lea, 1858) accepted as Pleuronaia barnesiana (I. Lea, 1838)
- Species Quadrula metanevra (Rafinesque, 1820) accepted as Theliderma metanevra (Rafinesque, 1820)
- Species Quadrula missouriensis (W. A. Marsh, 1901) accepted as Pleurobema sintoxia (Rafinesque, 1820)
- Species Quadrula mitchelli (C. T. Simpson, 1895) accepted as Fusconaia mitchelli (C. T. Simpson, 1895)
- Species Quadrula mortoni (Conrad, 1835) accepted as Cyclonaias mortoni (Conrad, 1835)
- Species Quadrula natosini (McLearn, 1929) †
- Species Quadrula negata (I. Lea, 1861) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula neislerii (I. Lea, 1858) accepted as Amblema neislerii (I. Lea, 1858)
- Species Quadrula nobilis (Conrad, 1854)
- Species Quadrula nodulata (Rafinesque, 1820) accepted as Pustulosa nodulata (Rafinesque, 1820)
- Species Quadrula obliqua (Lamarck, 1819) accepted as Pleurobema cordatum (Rafinesque, 1820)
- Species Quadrula obliquata (Rafinesque, 1820) accepted as Epioblasma obliquata (Rafinesque, 1820)
- Species Quadrula parkeri Geiser, 1911 accepted as Tritogonia verrucosa (Rafinesque, 1820)
- Species Quadrula perplicata (Conrad, 1841) accepted as Amblema plicata (Say, 1817)
- Species Quadrula petrina (A. Gould, 1855) accepted as Rotundaria petrina (A. Gould, 1855)
- Species Quadrula pilaris (I. Lea, 1840) accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula plena (I. Lea, 1840) accepted as Pleurobema plenum (I. Lea, 1840)
- Species Quadrula plicata (Say, 1817) accepted as Amblema plicata (Say, 1817)
- Species Quadrula primaevus (C. A. White, 1877) †
- Species Quadrula pustulata (I. Lea, 1831) accepted as Rotundaria nodulata (Rafinesque, 1820)
- Species Quadrula pustulosa (I. Lea, 1831) accepted as Rotundaria pustulosa (I. Lea, 1831)
- Species Quadrula quadrula (Rafinesque, 1820)
- Species Quadrula refulgens (I. Lea, 1868) accepted as Rotundaria refulgens (I. Lea, 1868)
- Species Quadrula rubida (I. Lea, 1861) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula rubidula Frierson, 1905 accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula rudis C. T. Simpson, 1900 accepted as Psorula rudis (C. T. Simpson, 1900)
- Species Quadrula rumphiana (I. Lea, 1852) accepted as Quadrula quadrula rumphiana (I. Lea, 1852)
- Species Quadrula salaputium E. von Martens, 1902 accepted as Lamprotula salaputium (E. von Martens, 1902)
- Species Quadrula sparsa (I. Lea, 1841) accepted as Theliderma sparsa (I. Lea, 1841)
- Species Quadrula speciosa (I. Lea, 1862) accepted as Quadrula apiculata (Say, 1829)
- Species Quadrula stapes (I. Lea, 1831) accepted as Theliderma stapes (I. Lea, 1831)
- Species Quadrula striatissima (J. G. Anthony, 1865) accepted as Pleurobema oviforme (Conrad, 1834)
- Species Quadrula subprimaevus [sic] † accepted as Theliderma subprimaevis (Dyer, 1930) †
- Species Quadrula subrotunda (I. Lea, 1831) accepted as Fusconaia subrotunda (I. Lea, 1831)
- Species Quadrula succissa (I. Lea, 1852) accepted as Rotundaria succissa (I. Lea, 1852)
- Species Quadrula supenawensis (Stanton & Hatcher, 1905) †
- Species Quadrula trapezoides (I. Lea, 1834) accepted as Plectomerus dombeyanus (Valenciennes, 1827)
- Species Quadrula trigona (I. Lea, 1834) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula tritogonia Ortmann, 1909 accepted as Tritogonia verrucosa (Rafinesque, 1820)
- Species Quadrula triumphans (B. H. Wright, 1898) accepted as Megalonaias nervosa (Rafinesque, 1820)
- Species Quadrula tuberculata (Rafinesque, 1820) accepted as Rotundaria tuberculata (Rafinesque, 1820)
- Species Quadrula tuberosa (I. Lea, 1840) accepted as Theliderma metanevra (Rafinesque, 1820)
- Species Quadrula undata (Barnes, 1823) accepted as Fusconaia flava (Rafinesque, 1820)
- Species Quadrula undulata (Barnes, 1823) accepted as Amblema plicata (Say, 1817)
- Species Quadrula valida (I. Lea, 1871) accepted as Pleuronaia barnesiana (I. Lea, 1838)
- Species Quadrula vallata (I. Lea, 1868) accepted as Rotundaria asperata (I. Lea, 1861)
- Species Quadrula verrucosa (Rafinesque, 1820)
- Genus Quaduila Rafinesque, 1820 accepted as Quadrula Rafinesque, 1820
- Genus Telederma Swainson, 1840 accepted as Theliderma Swainson, 1840
- Genus Theliderma Swainson, 1840 (7)
- Genus Thelyderma Agassiz, 1846 accepted as Theliderma Swainson, 1840
- Genus Tritigonia Agassiz, 1852 accepted as Tritogonia Agassiz, 1852
- Genus Tritogonia Agassiz, 1852 accepted as Quadrula Rafinesque, 1820 (1)
- Genus Uniomerus Conrad, 1853 (5)
- Genus Symphinota [sic] accepted as Symphynota I. Lea, 1829
- Genus Symphonota [sic] accepted as Symphynota I. Lea, 1829
- Subfamily Anodontinae Rafinesque, 1820 accepted as Anodontini Rafinesque, 1820
- Subfamily Cuneopsinae Mongin, 1963 accepted as Oxynaiini Starobogatov, 1970
- Subfamily Gonideinae Ortmann, 1916 (185)
- Subfamily Heudeaninae Modell, 1942 accepted as Gonideinae Ortmann, 1916 (1)
- Subfamily Hyriopsinae Modell, 1942 accepted as Rectidentini Modell, 1942
- Subfamily Lamprotulinae Modell, 1942 accepted as Lamprotulini Modell, 1942
- Subfamily Lampsilinae Ihering, 1901 accepted as Lampsilini Ihering, 1901
- Subfamily Leguminaiinae Starobogatov, 1970 accepted as Gonideini Ortmann, 1916
- Subfamily Limnoscaphinae Lindholm, 1932 accepted as Rectidentini Modell, 1942
- Subfamily Margaritaninae Ortmann, 1910 accepted as Margaritiferinae J. Henderson, 1929 (1910)
- Subfamily Megalonaiadinae Heard & Guckert, 1971 accepted as Quadrulini Ihering, 1901
- Subfamily Modellnaiinae Brandt, 1974 (1)
- Subfamily Nodulariinae Starobogatov & Zatravkin, 1987 accepted as Nodulariini Starobogatov & Zatravkin, 1987
- Subfamily Parreysiinae J. Henderson, 1935 (150)
- Subfamily Physunioninae Starobogatov, 1970 accepted as Contradentini Modell, 1942
- Subfamily Pseudanodontinae Stadnichenko, 1984 accepted as Anodontini Rafinesque, 1820
- Subfamily Pseudodontinae Frierson, 1927 (60)
- Subfamily Psilunioninae Starobogatov, 1970
- Subfamily Qiyangiinae J.-H. Chen, 1983 † (66)
- Subfamily Quadrulinae Ihering, 1901 accepted as Quadrulini Ihering, 1901
- Subfamily Rectidentinae Modell, 1942 (134)
- Subfamily Strophitinae Starobogatov, 1970 accepted as Anodontini Rafinesque, 1820
- Subfamily Unionidae incertae sedis (357)
- Subfamily Unioninae Rafinesque, 1820 (790)
- Genus Strophitinae M. E. Gordon, 1981 accepted as Strophitinae Starobogatov, 1970
- Family Deccanoidea N. H. Shah & Patel, 2024 † accepted as Deccanoidoidea N. H. Shah & Patel, 2024 †
- Family Pachycardiidae L. R. Cox, 1961 † accepted as Trigonodidae Modell, 1942 †
- Family Silesunionina Skawina & Dzik, 2011 † accepted as Silesunionoidea Skawina & Dzik, 2011 †
- Genus Araripenaia V. R. Silva et al., 2020 † (1)
- Family Lyrodesmatidae P. Fischer, 1886 † (8)
- Family Pseudarcidae Scarlato & Starobogatov, 1979 † (3)
- Family Thoraliidae N. J. Morris, 1980 †
- Superorder Heteroconchia incertae sedis † (1)
- Infraclass Pteriomorphia (6 644)
- Subclass Bivalvia incertae sedis (7)
- Subclass Palaeotaxodonta accepted as Nuculida
- Subclass Paleoheterodonta accepted as Palaeoheterodonta
- Subclass Protobranchia (1 365)
- Infraclass Cryptodonta † (342)
- Class Caudofoveata (143)
- Class Cephalopoda (1 832)
- Class Conchifera accepted as Bivalvia
- Class Cricoconarida † (1)
- Class Gastropoda (102 679)
- Class Lamellibranchiata accepted as Bivalvia
- Class Loricata accepted as Polyplacophora
- Class Mollusca incertae sedis † (372)
- Class Monoplacophora (229)
- Class Pelecypoda accepted as Bivalvia
- Class Polyplacophora (1 377)
- Class Polyplaxiphora accepted as Polyplacophora
- Class Rostroconchia † (64)
- Class Scaphopoda (752)
- Class Solenoconchia accepted as Scaphopoda
- Class Solenogastres (313)
- Subclass Chaetodermomorpha accepted as Caudofoveata